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Opana ER

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Oxymorphone extended-release is used to help relieve severe ongoing pain. It belongs to a class of drugs known as long-acting opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.

Do not use the extended-release form of oxymorphone to relieve pain that is mild or that will go away in a few days. This medication is not for occasional (“as needed”) use.

 

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How to use Opana ER

Read the Medication Guide provided by your pharmacist before you start taking oxymorphone extended-release and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication on a regular schedule as directed by your doctor, not as needed for sudden (breakthrough) pain.

Take this medication by mouth without food (at least 1 hour before or 2 hours after eating) as directed by your doctor, usually every 12 hours. Swallow the tablets whole. Do not break, chew, dissolve, or crush them. Do not pre-soak, lick, or wet the tablets before putting them in your mouth. Take one tablet at a time with enough water to completely swallow the tablet. If you have nausea, ask your doctor or pharmacist about ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

Before you start using this medication, ask your doctor or pharmacist if you should stop or change how you use your other opioid medication(s). Other pain relievers (such as acetaminophenibuprofen) may also be prescribed. Ask your doctor or pharmacist about using oxymorphone safely with other drugs.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Side Effects

Nauseavomitingheadacheconstipationdry mouth, mild itchinglightheadednessdizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacistpromptly.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Sometimes a soft mass that looks like the tablet may appear in your stool. This effect is harmless because your body has already absorbed the medication.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication donot have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, confusion, hallucinations), stomach/abdominal painvisionchanges, slow/fast heartbeat, difficulty urinating, difficulty swallowing this medication (such as choking, gagging), signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss).

Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, faintingseizure, severe drowsiness/difficulty waking up.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rashitching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Before taking oxymorphone, tell your doctor or pharmacist if you are allergic to it; or to other opioid pain medications (such as codeine, morphineoxycodone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthmasleep apneachronic obstructive pulmonary diseaseCOPD), gallbladder disease, kidney diseaseliver disease, mental/mood disorders (such as confusion, depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addictionto drugs/alcohol), stomach/intestinal problems (such as blockage, surgery, constipationdiarrhea due to infection, paralytic ileus), cancer of the esophagus or colon, difficulty swallowing, disease of the pancreas (pancreatitis), difficulty urinating (such as due to enlarged prostate).

Older adults may be more sensitive to the side effects of the drug, especially confusion, dizziness, drowsiness, slow/shallow breathing.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor. (See also Warning section.)

It is unknown if this drug passes into breast milk. However, similar drugs pass into breast milk and may rarely have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacistDo not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: products that contain alcohol (such as cough-and-cold syrups), certain pain medications (mixed opioid agonist-antagonists such as pentazocine, nalbuphine, butorphanol), naltrexone.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolamlorazepam, zolpidem), muscle relaxants (such as carisoprodolcyclobenzaprine), or antihistamines (such as cetirizinediphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including amylase and lipaselevels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Additional information

Miligram

5, 10, 40

Quantity

50, 100, 150

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